Drugs that does not cross Blood Brain Barrier______________?
Correct answer: B. Neostigmine
- A. Atropine
- B. Neostigmine
- C. Physostigmine
- D. Scopolamine
Explanation
Neostigmine is a permanently charged quaternary ammonium compound, so it does not significantly cross the blood-brain barrier. Physostigmine crosses it readily, while atropine and scopolamine are tertiary amines that enter the CNS.
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