Asked in UHS MDCAT 2013 2013Moderate

Cystic fibrosis patients lack a gene that codes for trans-membrane carriers of?

Correct answer: B. Cl- ions

  • A. Na+ ions
  • B. Cl- ions
  • C. Ca++ ions
  • D. K+ ions

Explanation

Cystic fibrosis is a genetic disorder caused by a mutation in the cystic fibrosis trans-membrane conductance regulator (CFTR) gene. This gene codes for a protein involved in the transport of chloride ions (Cl-) across cell membranes. In individuals with cystic fibrosis, the CFTR protein is either absent or dysfunctional, leading to impaired chloride ion transport. The imbalance of chloride ions affects the movement of water in and out of cells, particularly in the respiratory and digestive systems. This results in the production of thick, sticky mucus that clogs the airways and obstructs the pancreas, leading to various symptoms and complications associated with cystic fibrosis

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