Cleavage of IgG molecule by Papin gives rise to:One Fc fragment and two Fab fragments_______________?
Correct answer: A. One Fc fragment and two Fab fragments
- A. One Fc fragment and two Fab fragments
- B. One Fc fragment and four Fab fragments
- C. Two Fc fragments and two Fab fragments
- D. Two Fc fragment and one Fab fragment
Explanation
Papain cleaves IgG above its hinge region, producing two antigen-binding Fab fragments and one crystallisable Fc fragment. Pepsin differs by leaving an F(ab′)2 fragment and digesting most of the Fc portion.
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