Choose the wrong statement regarding AIDS:

Correct answer: C. HIV selectively infects and kills B-lymphocytes.

  • A. AIDS is an immunodeficiency disease.
  • B. It is caused by the retrovirus HIV.
  • C. HIV selectively infects and kills B-lymphocytes.
  • D. Retroviruses have RNA genomes that replicate a DNA intermediates.

Explanation

HIV (Human Immunodeficiency Virus) is a retrovirus that primarily targets the immune system, leading to immune deficiency. Being a retrovirus, HIV carries single-stranded RNA as its genetic material and uses the enzyme reverse transcriptase to convert its RNA into DNA after entering a host cell. This viral DNA is then integrated into the host genome, allowing the virus to replicate and produce new viral particles. HIV mainly attacks CD4+ T lymphocytes, macrophages, and dendritic cells, which are central to immune coordination, leading to a progressive decline in immune function and susceptibility to opportunistic infections.The option stating that HIV attacks B-lymphocytes is incorrect. While B cells are important for antibody production, they do not express CD4 receptors, so HIV cannot directly infect them. The immune deficiency seen in HIV infection occurs indirectly, because the loss of CD4+ T cells impairs the activation and regulation of B cells, reducing the body's ability to mount effective antibody responses. Thus, HIV targets the immune system primarily through CD4+ T cells, not B-lymphocytes.

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