Before entering the Krebs cycle, the pyruvate is first decarboxylated and oxidized into:
Correct answer: D. Acetyl-CoA
- A. Alpha ketoglutaric acid
- B. Citric acid
- C. Glyceric acid
- D. Acetyl-CoA
Explanation
Before entering the Krebs cycle, pyruvate is converted into acetyl-CoA through the link reaction, where it is decarboxylated and oxidized. Acetyl-CoA is a two-carbon molecule that combines with coenzyme A and enters the Krebs cycle to produce energy-rich molecules like ATP, NADH, and FADH₂. Alpha-ketoglutaric acid is an intermediate of the Krebs cycle, formed later during the cycle, not directly from pyruvate. Citric acid is the first product of the Krebs cycle, formed when acetyl-CoA combines with oxaloacetate, so it is also not directly produced from pyruvate. Glyceric acid is a three-carbon compound unrelated to the conversion of pyruvate to acetyl-CoA and does not play a role in the Krebs cycle. Therefore, acetyl-CoA is the correct product formed from pyruvate before entering the Krebs cycle.
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About Bioenergetics
Cellular respiration explains how cells release energy from glucose through glycolysis, the link reaction, Krebs cycle and electron transport chain. It includes ATP production, substrate-level and oxidative phosphorylation, aerobic versus anaerobic respiration, and the roles of mitochondria, oxygen and fermentation in energy transfer.
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