All of the following about prostaglandins and leukotriene are correct except________________?
Correct answer: D. COX-1 is inducible in many tissues
- A. Arachidonic acid is metabolized to form prostaglandins and leukotrienes
- B. Leukotrienes cause bronchoconstriction
- C. COX is induced by cytokines at the site of inflammation
- D. COX-1 is inducible in many tissues
Explanation
COX-1 is generally constitutive and maintains normal gastric, renal and platelet functions, whereas inducible COX-2 is increased by cytokines during inflammation. Arachidonic acid produces both prostaglandins and leukotrienes, and leukotrienes can cause bronchoconstriction.
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