A young lady talking rifampicin and OCP together become pregnant, most probable cause is____________?
Correct answer: A. Rifampicin causes hepatic enzyme induction and increase metabolism of OCP's
- A. Rifampicin causes hepatic enzyme induction and increase metabolism of OCP's
- B. Decreased absorption of OCP's
- C. Obstruction of fallopian tubes
- D. Increase excretion of OCP's
Explanation
Rifampicin strongly induces hepatic CYP450 enzymes, especially CYP3A4, which accelerates metabolism of oestrogen and progestin components of oral contraceptives. The resulting lower hormone concentrations can cause contraceptive failure.
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Practise Antimicrobial Agents
144 free Antimicrobial Agents MCQs from Pharmacology, each with the correct answer and an explanation. Unlimited attempts, no account needed.
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