A vaccine containing killed organisms generally requires an adjuvant mainly because killed organisms:
Correct answer: D. Provide weaker stimulation of cellular immunity
- A. Replicate rapidly in host tissues
- B. Cannot be recognized by antibodies
- C. Always cause severe local disease
- D. Provide weaker stimulation of cellular immunity
Explanation
Killed organisms cannot replicate and often produce a weaker or shorter immune response, so an adjuvant can enhance antigen presentation and immune stimulation. They can still be recognized by antibodies and normally do not cause disease by replication.
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About Veterinary Microbiology and Immunology
Covers the structure, classification, growth and transmission of bacteria, viruses, fungi and other disease causing microorganisms in animals. It explains innate and acquired immunity, antibodies, antigens, vaccination, hypersensitivity and diagnostic methods, while distinguishing infectious agents from the immune responses they produce.
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