A pure drug is administered as a sphere and as a cube. The amount of drug is the same in the two tablets. Assuming that the shape and size do not influence the mass transfer, the ratio of rate of dissolution in water at t = 0 for the cubic to spherical tablet is___________________?

Correct answer: C. 1.24

  • A. 0.54
  • B. 1.04
  • C. 1.24
  • D. 1.94

Explanation

For equal drug volume, the initial dissolution rate is proportional to exposed surface area. A cube has about 1.24 times the surface area of an equal-volume sphere, so its initial dissolution rate has the same ratio.

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