A competitive inhibitor of succinic dehydrogenase is:
Correct answer: B. Malonate
- A. α-ketoglutarate
- B. Malonate
- C. Pyruvate
- D. Oxaloacetate
Explanation
Malonate or oxaloacetate resemble succinate in structure and inhibit the activity of succinate dehydrogenase. Such competitive inhibitors are often used in control of bacterial pathogen.
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Enzymes are biological catalysts that lower activation energy without being consumed, and their specificity is explained by the lock and key and induced fit models. Work includes the effects of temperature, pH and substrate concentration on reaction rate, plus competitive and non-competitive inhibition and how these differ.
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