USMLE Step 1 Syllabus 2026

The complete subject-wise syllabus for USMLE Step 1, as set by NBME / FSMB (ECFMG for international graduates). Work through it one topic at a time: solve the MCQs on a topic until you are consistently above 80 percent before moving to the next.

• •Pathology: approximately 25 MCQs
• •Physiology: approximately 20 MCQs
• •Pharmacology: approximately 17 MCQs
• •Microbiology: approximately 13 MCQs
• •Biochemistry: approximately 13 MCQs
• •General Anatomy: approximately 12 MCQs