Asked in UHS MDCAT 2012 2012Moderate

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Correct answer: A. Acylation

  • A. Acylation
  • B. Carbonyl reduction
  • C. Alkylation
  • D. Formylation

Explanation

The introduction of an RC(O)+ group (also called an acyl group) in benzene is called acylation. This reaction is typically carried out using a catalyst such as aluminium chloride (AlCl3) or iron chloride (FeCl3). During the reaction, the catalyst activates the acylating agent such as acetyl chloride (CH3COCl) by removing a halide ion, creating an acylium ion (RC(O)+) that is then attacked by the benzene ring. The final product is an aromatic ketone.

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About Benzene and Aromatic Compounds

Benzene has a planar ring of delocalised π electrons, giving aromatic stability and equal carbon-carbon bond lengths. The topic covers resonance, electrophilic substitution reactions such as nitration, halogenation, sulphonation and Friedel-Crafts reactions, along with substituent effects and the distinction between substitution in benzene and addition in ordinary alkenes.

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