Strong Nucleophile in polar aprotic solvent?
Correct answer: A. Flouride ion
- A. Flouride ion
- B. Bromide ion
- C. Chloride ion
- D. Iodide ion
Explanation
In a polar aprotic solvent, fluoride ion is strongly nucleophilic because it is not extensively hydrogen-bonded or solvated by the solvent. The likely mistake is choosing iodide ion, which is the stronger nucleophile in polar protic solvents but is more heavily solvated relative to fluoride in polar aprotic media.
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About Nucleophilic Substitution
Nucleophilic substitution replaces a leaving group in an alkyl halide when an electron-rich nucleophile attacks the carbon atom. The topic compares SN1 and SN2 mechanisms, including reaction conditions, substrate structure, solvent effects, nucleophile strength, carbocation formation and stereochemical changes, and distinguishes substitution from elimination.
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